TY - JOUR

T1 - Ti40Zr10Cu36Pd14 bulk metallic glass as oral implant material

AU - Rezvan, Amir

AU - Sharifikolouei, Elham

AU - Soprunyuk, Viktor

AU - Schranz, Wilfried

AU - Todt, Juraj

AU - Lassnig, Alice

AU - Gammer, Christoph

AU - Sifferlinger, Nikolaus August

AU - Asci, Atacan

AU - Okulov, Ilya

AU - Schlögl, Sandra

AU - Keckes, Jozef

AU - Najmi, Ziba

AU - Cochis, Andrea

AU - Scalia, Alessandro Calogero

AU - Rimondini, Lia

AU - Sarac, Baran

AU - Eckert, Jürgen

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023/8/16

Y1 - 2023/8/16

N2 - The application of highly biocompatible advanced materials leads to fewer complications and more successful medical treatments. This study proposes Ti40Zr10Cu36Pd14 bulk metallic glass (BMG) as an oral implant material and provides insights into its possible processing routes, where high-temperature compression molding via an optimized process is adopted to both evaluate the thermoplastic net-shaping kinetics and tune the specific properties of the alloy. We present processed BMGs and BMG composites of the same composition with improved thermomechanical stability, from which high strength retention at temperatures, compared to the cast glass, by above 100 K higher is registered via dynamic mechanical analysis. ∼100 nm thin surface layers comprised of Ti, Cu, and Zr oxides form at the surface of the alloys, as identified by high-resolution transmission microscopy. Also, ∼4 orders of magnitude lower passivation current density along with ∼2 orders of magnitude lower corrosion current density of the processed glass compared to the values of the as-cast state confirms an extremely high stability in a 0.9 wt% saline environment which can be linked to surface hydrophobicity. Cytocompatibility analysis conducted by seeding human gingival fibroblast cells directly onto the thermoplastically formed Ti40Zr10Cu36Pd14 BMG reveals no adverse effect on cytocompatibility. On the other hand, the formation of a nanoscale oxide layer on the thermoplastically formed samples leads to significantly higher cell attachments on the surface.

AB - The application of highly biocompatible advanced materials leads to fewer complications and more successful medical treatments. This study proposes Ti40Zr10Cu36Pd14 bulk metallic glass (BMG) as an oral implant material and provides insights into its possible processing routes, where high-temperature compression molding via an optimized process is adopted to both evaluate the thermoplastic net-shaping kinetics and tune the specific properties of the alloy. We present processed BMGs and BMG composites of the same composition with improved thermomechanical stability, from which high strength retention at temperatures, compared to the cast glass, by above 100 K higher is registered via dynamic mechanical analysis. ∼100 nm thin surface layers comprised of Ti, Cu, and Zr oxides form at the surface of the alloys, as identified by high-resolution transmission microscopy. Also, ∼4 orders of magnitude lower passivation current density along with ∼2 orders of magnitude lower corrosion current density of the processed glass compared to the values of the as-cast state confirms an extremely high stability in a 0.9 wt% saline environment which can be linked to surface hydrophobicity. Cytocompatibility analysis conducted by seeding human gingival fibroblast cells directly onto the thermoplastically formed Ti40Zr10Cu36Pd14 BMG reveals no adverse effect on cytocompatibility. On the other hand, the formation of a nanoscale oxide layer on the thermoplastically formed samples leads to significantly higher cell attachments on the surface.

KW - Bulk metallic glass

KW - Cytocompatible

KW - Mechanical performance

KW - Oral implant

KW - Structure

KW - Thermoplastic net-shaping

KW - Viscoelastic behavior

UR - http://www.scopus.com/inward/record.url?scp=85169835791&partnerID=8YFLogxK

U2 - 10.1016/j.matdes.2023.112256

DO - 10.1016/j.matdes.2023.112256

M3 - Article

AN - SCOPUS:85169835791

VL - 233.2023

JO - Materials and Design

JF - Materials and Design

SN - 0264-1275

M1 - 112256

ER -