The transport industry is currently confronted with the challenge of reducing its reliance on fossil fuels in order to facilitate the decarbonisation of its processes. The objective is to transition to alternative fuels in conjunction with other transport concepts, such as combined transport. In order to achieve this objective, this thesis will analyse the currently available future-oriented drive technologies and integrate those identified as the most promising drives into a simulation framework. Based on several case studies and scenarios, characteristics such as costs and emissions as well as challenges, such as time effects on the transport processes, of the individual alternatives are worked out, analysed and compared. The results of the simulation runs are intended to provide an overview of the characteristics of the current selection of drive concepts and to offer companies recommendations regarding fleet conversion. On the one hand, the results indicate that battery electric drives offer a cost and partial emission advantage over vehicles powered by fossil fuels. On the other hand, however, there is also the significant disadvantage of increased planning and time expenditure. Charging processes imply a considerable additional time factor. Regardless of the drive technology, the supply infrastructure required for alternative transport remains scarce, and route planning is complex. The results of the simulation runs are limited to operating costs. Differences in subsidies, depreciation, or purchase prices of the drive technologies are not included. Furthermore, it is assumed that unlimited vehicle availability and maximum range capacity are facilitated by either company-owned or public infrastructure at the starting point.