An appealing idea to material scientists is to characterize the mechanical behavior of materials with minimal experimental effort while guaranteeing highly reliable results. Nanoindentation is a candidate technique to reach this objective. Though it is already a standard method to extract hardness and Young's modulus, the technique is not yet fully exploited. The authors demonstrate on the example of Ni and W, with microstructures ranging from single crystalline to nanocrystalline dimensions, how Hall–Petch parameters and flow curves can be extracted by using four pyramidal tips with varying apex angle. Applying appropriate definitions of indentation stress and strain and considering the indentation size effect, the obtained values coincidence well with literature values determined by uniaxial tests.