Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials

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Standard

Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials. / Maver, Tina; Maver, Uroš; Mostegel, Florian et al.
In: Cellulose, Vol. 22.2015, No. February, 2015, p. 749-761.

Research output: Contribution to journal › Article › Research › peer-review

Harvard

Maver, T, Maver, U, Mostegel, F, Grießer, T, Spirk, S, Smrke, DM & Stana-Kleinschek, K 2015, 'Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials', Cellulose, vol. 22.2015, no. February, pp. 749-761. https://doi.org/10.1007/s10570-014-0515-9

APA

Maver, T., Maver, U., Mostegel, F., Grießer, T., Spirk, S., Smrke, D. M., & Stana-Kleinschek, K. (2015). Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials. Cellulose, 22.2015(February), 749-761. https://doi.org/10.1007/s10570-014-0515-9

Vancouver

Maver T, Maver U, Mostegel F, Grießer T, Spirk S, Smrke DM et al. Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials. Cellulose. 2015;22.2015(February):749-761. Epub 2014 Nov 29. doi: 10.1007/s10570-014-0515-9

Author

Maver, Tina ; Maver, Uroš ; Mostegel, Florian et al. / Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials. In: Cellulose. 2015 ; Vol. 22.2015, No. February. pp. 749-761.

Bibtex - Download

@article{f9f4decd61344ee5a33fc5ad115bcd97,
title = "Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials",
abstract = "In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DSSi:2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV–Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.",
author = "Tina Maver and Uro{\v s} Maver and Florian Mostegel and Thomas Grie{\ss}er and Stefan Spirk and Smrke, {Dragica Maja} and Karin Stana-Kleinschek",
year = "2015",
doi = "10.1007/s10570-014-0515-9",
language = "English",
volume = "22.2015",
pages = "749--761",
journal = "Cellulose",
issn = "0969-0239",
publisher = "Springer Netherlands",
number = "February",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials

AU - Maver, Tina

AU - Maver, Uroš

AU - Mostegel, Florian

AU - Grießer, Thomas

AU - Spirk, Stefan

AU - Smrke, Dragica Maja

AU - Stana-Kleinschek, Karin

PY - 2015

Y1 - 2015

N2 - In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DSSi:2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV–Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.

AB - In this paper, the use of ultrathin cellulose supports as platform for the incorporation of analgesic drugs in wound dressings is proposed. As a model drug, diclofenac (DCF) is chosen, which is commonly used in pain easing medical treatments. The DCF containing cellulose films are prepared by mixing solutions of trimethylsilyl cellulose (DSSi:2.5) with DCF dissolved in THF. After depositing the material on a solid surface by spin-coating, the films are subjected to vapor-phase hydrolysis using 3 M HCl in order to achieve regeneration of cellulose. The release of DCF from these films over time is studied by UV–Vis. Upon deposition of additional layers of cellulose that do not contain DCF, the release from these films can be decelerated significantly. The release kinetics from these films is very similar to those of viscose fibers impregnated with DCF solutions. These studies indicate a potential use of cellulose thin films as model platform for viscose based wound dressings.

U2 - 10.1007/s10570-014-0515-9

DO - 10.1007/s10570-014-0515-9

M3 - Article

VL - 22.2015

SP - 749

EP - 761

JO - Cellulose

JF - Cellulose

SN - 0969-0239

IS - February

ER -

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