This master's thesis investigates the practical application of microstructure simulations using the DAMASK simulation software (Düsseldorfer Advanced Material Simulation Kit) for cyclic loads. The focus is on two aluminium casting alloys, EN AC 42100 and EN AC 46200, which were previously characterised in the Christian Doppler Laboratory for Manufacturing Process based Component Design. The study performs a comparative analysis between experimental and simulated samples. The material's consecutive parameters were approximated through literature research and parameter variation. Grain size and grain orientation were derived from physical samples. Changes in the microstructure, particularly plastic deformations resulting from introduced deformation, were analysed. EBSD measurements of the samples before and after loading processes were used to understand and visualize these changes. Although there have been remarkable successes, such as the convergence between experimental and simulated data in material approximation based on uniaxial tensile tests, it is important to note the limitations of this experimental procedure. As a result, there may be a discrepancy between experimental and simulated low-cycle fatigue tests.