Systems-level organization of yeast methylotrophic lifestyle
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in: BMC biology, Jahrgang 13.2015, Nr. 1, 80, 23.09.2015.
Publikationen: Beitrag in Fachzeitschrift › Artikel › Forschung › (peer-reviewed)
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TY - JOUR
T1 - Systems-level organization of yeast methylotrophic lifestyle
AU - Rußmayer, Hannes
AU - Buchetics, Markus
AU - Gruber, Clemens
AU - Valli, Minoska
AU - Grillitsch, Karlheinz
AU - Modarres, Gerda
AU - Guerrasio, Raffaele
AU - Klavins, Kristaps
AU - Neubauer, Stefan
AU - Drexler, Hedda
AU - Steiger, Matthias G.
AU - Troyer, Christina
AU - Al Chalabi, Ali
AU - Krebiehl, Guido
AU - Sonntag, Denise
AU - Zellnig, Günther
AU - Daum, Günther
AU - Graf, Alexandra B.
AU - Altmann, Friedrich
AU - Koellensperger, Gunda
AU - Hann, Stephan
AU - Sauer, Michael
AU - Mattanovich, Diethard
AU - Gasser, Brigitte
N1 - Publisher Copyright: © 2015 Rußmayer et al.
PY - 2015/9/23
Y1 - 2015/9/23
N2 - Some yeasts have evolved a methylotrophic lifestyle enabling them to utilize the single carbon compound methanol as a carbon and energy source. Among them, Pichia pastoris (syn. Komagataella sp.) is frequently used for the production of heterologous proteins and also serves as a model organism for organelle research. Our current knowledge of methylotrophic lifestyle mainly derives from sophisticated biochemical studies which identified many key methanol utilization enzymes such as alcohol oxidase and dihydroxyacetone synthase and their localization to the peroxisomes. C1 assimilation is supposed to involve the pentose phosphate pathway, but details of these reactions are not known to date.
AB - Some yeasts have evolved a methylotrophic lifestyle enabling them to utilize the single carbon compound methanol as a carbon and energy source. Among them, Pichia pastoris (syn. Komagataella sp.) is frequently used for the production of heterologous proteins and also serves as a model organism for organelle research. Our current knowledge of methylotrophic lifestyle mainly derives from sophisticated biochemical studies which identified many key methanol utilization enzymes such as alcohol oxidase and dihydroxyacetone synthase and their localization to the peroxisomes. C1 assimilation is supposed to involve the pentose phosphate pathway, but details of these reactions are not known to date.
KW - Metabolome
KW - Methanol
KW - Peroxisome
KW - Pichia pastoris
KW - Proteome
KW - Transcriptome
KW - Xylulose-monophosphate cycle
KW - Analytische Chemie
UR - http://www.scopus.com/inward/record.url?scp=84960429670&partnerID=8YFLogxK
U2 - 10.1186/s12915-015-0186-5
DO - 10.1186/s12915-015-0186-5
M3 - Article
C2 - 26400155
AN - SCOPUS:84960429670
VL - 13.2015
JO - BMC biology
JF - BMC biology
SN - 1741-7007
IS - 1
M1 - 80
ER -