The reverse water gas shift (rWGS) reaction represents a key technology for the utilization of CO2. This study presents experimental results which compare the performance of a commercially available nickel catalyst, two novel perovskite catalysts and Al2O3. In addition to the variations of the input gas composition, the operating conditions have been adjusted between 550 and 950 °C and 1 to 8 bara. The results reveal, on the one hand, that the nickel catalyst achieves thermodynamic equilibrium, resulting in high selectivity toward CO formation at elevated temperatures (950 °C) and pressures up to 6 bara. Higher catalyst loads suppress methane formation at certain operating points. On the other hand, the perovskite catalyst prevents methane formation even at low temperature (550 °C) and higher pressures up to 8 bara favor the CO formation. In consequence, methane formation is limited to less than 2 vol-% at 650 °C and 8 bara and the CO content in the product gas is significantly higher compared with the nickel catalyst. Al2O3 also shows catalytic activity and approaches to thermodynamic equilibrium at high temperature (950 °C) and 6 bara. The investigated novel perovskite catalysts have the potential to intensify the rWGS reaction towards a simpler reactor design and a highly efficient operation, also on a large-scale basis.