In-situ high-temperature microscopy techniques provide crucial insights into materials under non-ambient conditions. This study compares confocal laser scanning and scanning electron microscopy for material characterization at elevated temperatures. Thereby, investigations are made regarding their imaging capabilities, limitations, and the general information obtained. Two alloys, Cu-20 m.% Sn and W-10 m.% Re, are used as case studies to demonstrate the applicability of the techniques. By studying phenomena such as grain growth, phase transformations, and thermal crack, we gain important insights to understand mechanical properties and thermal behavior better. This comprehensive analysis aids in selecting the most appropriate microscopy technique based on the research objectives. Overall, this study helps advance high-temperature materials science and promotes progress in several areas requiring accurate materials characterization under high thermal conditions.