Aluminum alloys with low mass are ideal material choices for aerostructures that should withstand the tough corrosion and mechanical conditions. The deterioration of mechanical properties due to absorption of hydrogen from the water vapor in the atmosphere made the aluminum alloys susceptible to hydrogen embrittlement in slow strain rate of loading. In aluminum alloys, it is well-known that the mechanisms and root causes of failure are related to the microstructure which is driven by different processing routes. In the present study, some selected processing routes are considered, and their effect on hydrogen embrittlement behavior of the aluminum alloys are studied. The study includes detailed analyses of microstructural features resulted from different processing routes, and the corresponding effects on trapping and transport of hydrogen are discussed. Different techniques e.g. thermal desorption spectroscopy, hydrogen microprint technique, X-ray diffraction, electron backscattered diffraction, simulation and modeling, and other relevant techniques are applied to elucidate the effect of selected processing routes on hydrogen embrittlement behavior. The results have utmost importance in the design of different materials processing routes for different industrial applications to minimize the possibility of hydrogen-assisted fracture.