Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputtering
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in: Applied surface science, Jahrgang 573.2022, Nr. 30 January, 151604, 30.01.2022.
Publikationen: Beitrag in Fachzeitschrift › Artikel › Forschung › (peer-reviewed)
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TY - JOUR
T1 - Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputtering
AU - Rashid, Saqib
AU - Vita, Gian Marco
AU - Persichetti, Luca
AU - Iucci, Giovanna
AU - Battocchio, Chiara
AU - Daniel, Rostislav
AU - Visaggio, Daniela
AU - Marsotto, Martina
AU - Visca, Paolo
AU - Bemporad, Edoardo
AU - Ascenzi, Paolo
AU - Capellini, Giovanni
AU - Sebastiani, Marco
AU - di Masi, Alessandra
N1 - Publisher Copyright: © 2021 Elsevier B.V.
PY - 2022/1/30
Y1 - 2022/1/30
N2 - Mechanical robustness, biocompatibility, and antibacterial performance are key features for materials suitable to be used in tissue engineering applications. In this work, we investigated the link existing between structural and functional properties of TiCu(Ag) thin films deposited by physical vapor deposition magnetron sputtering (MS-PVD) on Si substrates. Thin films were characterized by X-ray diffraction (XRD), nanoindentation, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The TiCu(Ag) films showed complete amorphous structure and improved mechanical properties in comparison with pure Ti films. However, for contents in excess of 20% Ag we observed the appearance of nanometric Ag crystallite. The TiCu(Ag) thin films displayed excellent biocompatibility properties, allowing adhesion and proliferation of the human fibroblasts MRC-5 cell line. Moreover, all the investigated TiCu(Ag) alloys display bactericidal properties, preventing the growth of both Pseudomonas aeruginosa and Staphylococcus aureus. Results obtained from biological tests have been correlated to the surface structure and microstructure of films. The excellent biocompatibility and bactericidal properties of these multifunctional thin films opens to their use in tissue engineering applications.
AB - Mechanical robustness, biocompatibility, and antibacterial performance are key features for materials suitable to be used in tissue engineering applications. In this work, we investigated the link existing between structural and functional properties of TiCu(Ag) thin films deposited by physical vapor deposition magnetron sputtering (MS-PVD) on Si substrates. Thin films were characterized by X-ray diffraction (XRD), nanoindentation, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The TiCu(Ag) films showed complete amorphous structure and improved mechanical properties in comparison with pure Ti films. However, for contents in excess of 20% Ag we observed the appearance of nanometric Ag crystallite. The TiCu(Ag) thin films displayed excellent biocompatibility properties, allowing adhesion and proliferation of the human fibroblasts MRC-5 cell line. Moreover, all the investigated TiCu(Ag) alloys display bactericidal properties, preventing the growth of both Pseudomonas aeruginosa and Staphylococcus aureus. Results obtained from biological tests have been correlated to the surface structure and microstructure of films. The excellent biocompatibility and bactericidal properties of these multifunctional thin films opens to their use in tissue engineering applications.
UR - http://www.scopus.com/inward/record.url?scp=85117338371&partnerID=8YFLogxK
U2 - 10.1016/j.apsusc.2021.151604
DO - 10.1016/j.apsusc.2021.151604
M3 - Article
VL - 573.2022
JO - Applied surface science
JF - Applied surface science
SN - 0169-4332
IS - 30 January
M1 - 151604
ER -
