The European industry is facing the major challenge of increasing the resource efficiency of their production in order to remain competitive. Especially for companies in the process and basic industries, the increase in efficiency is imperative to counteract trends in the business environment. The use of classical methods of production management for optimizing production and increasing efficiency in this specific production system is stretched to the limits. In this dissertation, a conversion model is developed based on the theory of production factors and the loss calculation of the Lean Philosophy, which allows systemic resource efficiency increase in complex production systems. To support the process of change, instruments have been designed to enable a holistic loss identification and reduction. To ensure the possibility of using the approach in practice, a study of the structures of the production systems of process and basic industries was conducted and the relevant internal and external factors were determined. A developed IT analysis tool supports the approach of increasing the resource efficiency of complex production systems in process and raw materials industry. The IT tool is used in a company of the non-ferrous metal industry and supports the people involved in the value creation process in the loss reduction and optimization of the production system.