Surface tension determines tissue shape and growth kinetics
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In: Science Advances, Vol. 5.2019, No. 9, eaav9394, 11.09.2019.
Research output: Contribution to journal › Article › Research › peer-review
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TY - JOUR
T1 - Surface tension determines tissue shape and growth kinetics
AU - Ehrig, Sebastian
AU - Schamberger, Barbara
AU - Bidan, Cecile M
AU - West, A.
AU - Jacobi, C.
AU - Lam, K.
AU - Kollmannsberger, P.
AU - Petersen, A.
AU - Tomancak, P.
AU - Kommareddy, K.
AU - Fischer, Franz-Dieter
AU - Fratzl, P.
AU - Dunlop, John W. C.
N1 - Publisher Copyright: Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
PY - 2019/9/11
Y1 - 2019/9/11
N2 - The collective self-organization of cells into three-dimensional structures can give rise to emergent physical properties such as fluid behavior. Here, we demonstrate that tissues growing on curved surfaces develop shapes with outer boundaries of constant mean curvature, similar to the energy minimizing forms of liquids wetting a surface. The amount of tissue formed depends on the shape of the substrate, with more tissue being deposited on highly concave surfaces, indicating a mechano-biological feedback mechanism. Inhibiting cell-contractility further revealed that active cellular forces are essential for generating sufficient surface stresses for the liquid-like behavior and growth of the tissue. This suggests that the mechanical signaling between cells and their physical environment, along with the continuous reorganization of cells and matrix is a key principle for the emergence of tissue shape.
AB - The collective self-organization of cells into three-dimensional structures can give rise to emergent physical properties such as fluid behavior. Here, we demonstrate that tissues growing on curved surfaces develop shapes with outer boundaries of constant mean curvature, similar to the energy minimizing forms of liquids wetting a surface. The amount of tissue formed depends on the shape of the substrate, with more tissue being deposited on highly concave surfaces, indicating a mechano-biological feedback mechanism. Inhibiting cell-contractility further revealed that active cellular forces are essential for generating sufficient surface stresses for the liquid-like behavior and growth of the tissue. This suggests that the mechanical signaling between cells and their physical environment, along with the continuous reorganization of cells and matrix is a key principle for the emergence of tissue shape.
UR - http://www.scopus.com/inward/record.url?scp=85072403207&partnerID=8YFLogxK
U2 - 10.1126/sciadv.aav9394
DO - 10.1126/sciadv.aav9394
M3 - Article
VL - 5.2019
JO - Science Advances
JF - Science Advances
SN - 2375-2548
IS - 9
M1 - eaav9394
ER -
