Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
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Authors
Organisational units
External Organisational units
- Universite Bourgogne Franche-Comte
- European Synchotron Radiation Facility
- University of Liege
- Photon Science, Deutsches Elektronen-Synchrotron DESY, Hamburg,
- European XFEL GmbH
- Ruđer Bošković Institute
- McGill University
- University of Warsaw
Abstract
Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.
Details
Original language | English |
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Pages (from-to) | 16332-16336 |
Number of pages | 5 |
Journal | Journal of the American Chemical Society |
Volume | 143.2021 |
Issue number | 40 |
Early online date | 28 Sept 2021 |
DOIs | |
Publication status | Published - 13 Oct 2021 |