Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

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Authors

  • Daniel Szczerba
  • Davin Tan
  • Jean-Louis Do
  • Hatem M. Titi
  • Siham Mouhtadi
  • Denis Chaumont
  • Maria del Carmen Marco de Lucas
  • Nicolas Geoffroy
  • Michel Meyer
  • Yoann Rousselin
  • Jessica M. Hudspeth
  • Valerie Schwanen
  • Ann-Christin Dippel
  • Oleh Ivashko
  • Olof Gutowski
  • Philipp Glaevecke
  • Vasilii Bazhenov
  • Mihails Arhangelskis
  • Ivan Halasz
  • Tomislav Friscic
  • Simon A.J. Kimber

External Organisational units

  • Universite Bourgogne Franche-Comte
  • European Synchotron Radiation Facility
  • University of Liege
  • Photon Science, Deutsches Elektronen-Synchrotron DESY, Hamburg,
  • European XFEL GmbH
  • Ruđer Bošković Institute
  • McGill University
  • University of Warsaw

Abstract

Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.

Details

Original languageEnglish
Pages (from-to)16332-16336
Number of pages5
JournalJournal of the American Chemical Society
Volume143.2021
Issue number40
Early online date28 Sept 2021
DOIs
Publication statusPublished - 13 Oct 2021