Rational use of hydrocarbon fuel is a priority for the development of the gas industry and the Russian economy. Virtually all gas turbine units at natural gas compressor stations operate in a simple cycle, in which the waste heat is rejected into the atmosphere, representing appreciable energy loss. The most rational way to utilize waste heat is the implementation of units that convert heat energy into electricity. In the current context, one of the most prospective technologies for waste heat recovery is the Organic Rankine Cycle (ORC). Questions of use of units based on ORC at the natural gas compressor stations and the selection of optimal working fluid operating parameters remain open and require additional researches. This study focusses on finding ways that enable the generation of electricity at natural gas compressors stations by utilization of waste heat. In this thesis, the impact of working fluid type on the net power output of ORC has been investigated. Furthermore, optimization of operating parameters of ORC has been studied. This work has been established based on the initial data taken from the booster compressor station of Yamburg gas field. Optimal operating parameters of the ORC working fluids were investigated taking into account the basics of thermodynamics and the practice of industrial operation. The results from this study can lead to the more complete utilization of waste heat of exhaust gases from gas turbine units and fuel gas economy. These results should improve the efficiency of gas turbine units at compressor stations as well as economic and environmental aspects.