Lightweight constructions are becoming more and more important, in addition to the demanded increase of efficiency, performance and weight savings, hybrid structures will be targeted as a tailor- made solutions in the future. Therefore, the Resin Transfer Molding (RTM)-process offers the possibility to produce these hybrid structures in a one-step process. In this context, it is necessary to understand the associated phenomena of the process. For this purpose, the design of experiments (DoE)-approach with a corresponding fractional factorial design was used to produce hybrid plates. The aim is to show possible effects on the quality of the plates by changing one or more setting variables. Therefore, the filling time, the plate bending, the maximum yieldable bending stress and the adhesion between the hybrid components were defined as suitable quality features and afterward tested in the form of deflection measurements, bending- and Single Lap Shear (SLS)- tests. In order to be able to determine the influence of the setting variables on the respective quality characteristic, main effects- and interaction diagrams as well as a variance analysis for each individual quality feature were created by using a statistics program. Thereby it turns out that the mass flow change, as well as the tool temperature as adjustment variables, significantly affect the quality of the hybrid plates. For an optimization of each individual quality characteristic, the ideal choice of the setting variables can differ. Therefore, if all quality features have to be optimized at the same time, a compromise must be found for a suitable setting. With this work, an understanding of the phenomena of the RTM-process was attained by using the DoE-approach.