In this work a method for a CFD simulation of the electrolyte flow in a copper electrorefining electrolysis cell is presented. The electrolyte flow is influenced by locally occurring mass transport and concentration differences as well as globally acting circulation processes. By coupling the results of the local and global simulation, the flow behavior could be successfully simulated. To verify the model indicator experiments were carried out at an electrolysis cell used in the industry. The results show a very good agreement with the simulation. Building on this new simulation method for copper refining electrolysis cells, an optimization of different cell parameters was carried out. The goal was to maximize the inhibitors distribution and activity. As a representation of all additives used in copper electrorefining electrolysis the behavior of glue was simulated. By varying different parameters such as the geometry and positioning of the electrolyte inlet or even using multiple electrolyte inlets the impact on the electrolyte flow and inhibitors distribution could be tested and finally an optimum could be found.