Optimizing the surface topography of cast iron crankshafts offers the opportunity to use this material as an alternative to steel in high-performance combustion engines. In the past, this was not possible due to the higher wear on bearing shells and the higher friction losses in relation to forged steel shafts. In order to find an optimized shaftmicro topography, the friction and wear behavior of steel and cast iron shafts with different surface treatments were compared to each other, using a combined physical (experimental) and a virtual (computational) simulation approach. The experiments were carried out with a rotary tribometer using a journal bearing test configuration with the possibility to test real-life bearing shells and shaft specimens, manufactured fromreal-life crankshafts. In the experiments, a polished steel shaft with low bearing wear was effective. The optimization of cast iron crankshafts by a novel surface treatment showed a significant reduction of bearing wear in relation to the classical surface finishing procedures of cast iron shafts. A computational simulation approach, considering the real-life micro topography by using the Navier-Stokes equations for the calculation of micro hydrodynamics, supports the assessment of fluid friction. The virtual simulation shows, in accordance to the experimental results, only a minor influence of the investigated shaft topographies on the fluid friction. Further optimization of shaft surfaces for journal bearing systems seems possible only by the usage of patterned micro topographies.