TY - JOUR

T1 - 3D-Printed Acrylated Soybean Oil Scaffolds with Vitrimeric Properties Reinforced by Tellurium-Doped Bioactive Glass

AU - Bergoglio, Matteo

AU - Kriehuber, Matthias

AU - Sölle, Bernhard

AU - Rossegger, Elisabeth

AU - Schlögl, Sandra

AU - Najmi, Ziba

AU - Cochis, Andrea

AU - Ferla, Federica

AU - Miola, Marta

AU - Vernè, Enrica

AU - Sangermano, Marco

N1 - Publisher Copyright: © 2024 by the authors.

PY - 2024/12/23

Y1 - 2024/12/23

N2 - In this study, we present novel, vitrimeric and biobased scaffolds that are designed for hard tissue applications, composed of acrylated, epoxidized soybean oil (AESO) and reinforced with bioactive glass that is Tellurium doped (BG-Te) and BG-Te silanized, to tune the mechanical and antibacterial properties. The manufacture’s method consisted of a DLP 3D-printing method, enabling precise resolution and the possibility to manufacture a hollow and complex structure. The resin formulation was optimized with a biobased, reactive diluent to adjust the viscosity for an optimal 3D-printing process. The in vitro biological evaluation of the 3D-printed scaffolds, combined with BG-Te and BG-Te-Sil, showed that the sample’s surfaces remained safe for hBMSCs’ attachment and proliferation. The number of S. aureus that adhered to the BG-Te was 87% and 54% lower than on the pristine (control) and BG-Te-Sil, respectively, with the eradication of microbiofilm aggregates. This work highlights the effect of the vitrimeric polymer matrix and doped, bioactive glass in manufacturing biocompatible, biobased, and antibacterial scaffold used in hard tissue application.

AB - In this study, we present novel, vitrimeric and biobased scaffolds that are designed for hard tissue applications, composed of acrylated, epoxidized soybean oil (AESO) and reinforced with bioactive glass that is Tellurium doped (BG-Te) and BG-Te silanized, to tune the mechanical and antibacterial properties. The manufacture’s method consisted of a DLP 3D-printing method, enabling precise resolution and the possibility to manufacture a hollow and complex structure. The resin formulation was optimized with a biobased, reactive diluent to adjust the viscosity for an optimal 3D-printing process. The in vitro biological evaluation of the 3D-printed scaffolds, combined with BG-Te and BG-Te-Sil, showed that the sample’s surfaces remained safe for hBMSCs’ attachment and proliferation. The number of S. aureus that adhered to the BG-Te was 87% and 54% lower than on the pristine (control) and BG-Te-Sil, respectively, with the eradication of microbiofilm aggregates. This work highlights the effect of the vitrimeric polymer matrix and doped, bioactive glass in manufacturing biocompatible, biobased, and antibacterial scaffold used in hard tissue application.

KW - 3D-printed scaffolds

KW - dynamic polymer networks

KW - tellurium-doped bioactive glass

UR - http://www.scopus.com/inward/record.url?scp=85213230208&partnerID=8YFLogxK

U2 - 10.3390/polym16243614

DO - 10.3390/polym16243614

M3 - Article

AN - SCOPUS:85213230208

VL - 16.2024

JO - Polymers

JF - Polymers

SN - 2073-4360

IS - 24

M1 - 3614

ER -