Industry 4.0 provides a variety of concepts and technologies to create competitive advantages for industrial enterprises and small- and medium-sized enterprises as well. Thereby, the successful implementation of new concepts and technologies in the areas of interconnectivity, digitalization, and automatization is dependent on a multitude of complex requirements. Based on expert workshops and an international survey, the authors developed and preliminarily validated a set of Logistics 4.0-related requirements for the effective implementation of Industry 4.0 in manufacturing enterprises. In this paper, the authors compare and discuss significant differences regarding the requirements of Central-European and South-East-Asian enterprises. Moreover, based on the empirical results, future directions for both enterprises and research are outlined and discussed in the course of this study.