Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
Publikationen: Beitrag in Fachzeitschrift › Artikel › Forschung › (peer-reviewed)
Autoren
Organisationseinheiten
Externe Organisationseinheiten
- Universite Bourgogne Franche-Comte
- European Synchotron Radiation Facility
- University of Liège
- Deutsches Elektronen-Synchrotron DESY
- European XFEL GmbH
- Institut Ruđer Bošković
- McGill University, Montreal
- University of Warsaw
Abstract
Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 16332-16336 |
Seitenumfang | 5 |
Fachzeitschrift | Journal of the American Chemical Society |
Jahrgang | 143.2021 |
Ausgabenummer | 40 |
Frühes Online-Datum | 28 Sept. 2021 |
DOIs | |
Status | Veröffentlicht - 13 Okt. 2021 |