Specific surface textures may reduce the friction and increase the lifting forces in lubricated contacts. For the detrimental operating condition of mixed friction, wear is induced by the solid contact. In this study, a methodology for wear calculation in textured, lubricated contacts is presented that considers the wear-induced surface topography evolution. Based on the Reynolds differential equation, the mass-conserving cavitation model according to Jakobsson, Floberg, and Olsson (JFO), a wear-dependent asperity contact pressure curve and the wear equation according to Archard, wear in a wedge-shaped, textured lubrication gap was calculated. The results show the wear behavior of textured lubrication gaps. Based on the wear simulations, the tribological behavior of the textured surfaces compared to smooth surfaces is discussed. It is evident that textures, which improve the tribological performance in the hydrodynamic lubrication regime, are not necessarily associated with low wear values in a lubrication condition in the mixed friction regime. The analysis of the wear-dependent parameters initially showed a ‘recovery’ of the tribological system with increasing wear until the performance decreased again after a specific reversal point. This behavior is attributed to the relative position of the surface textures in the lubrication gap.