Molecular structure and reinforcement heavily influence the crack growth resistance of polypropylene materials. Aim of this study is to investigate the fatigue behavior of different unreinforced and reinforced tough polypropylene materials used for piping applications. Due to high resistance against crack growth, these materials cannot be tested in the application relevant quasi-brittle failure mode within feasible amounts of time. In this work, the new cyclic cracked round bar test, developed for tough polyethylene materials, has been examined as a possible method to characterize this important type of failure mode in homo-, random-, and reinforced polypropylene. Even though molecular mass distribution, which is often used to explain differences in crack growth resistance of polymers, was similar for unreinforced materials, fatigue lifetimes differed greatly. The mismatch of molecular mass and fatigue lifetime was mainly attributed to the different buildup and morphology of the base polymer.