The Austrian industrial sector is a significant contributor to the national greenhouse gas emissions and energy consumption, making its transformation towards climate neutrality by 2040 essential. A promising strategy to reduce environmental impact and energy use is energy-based industrial symbiosis. This work explores how energy-based industrial symbiosis potentials will evolve in climate-neutral industrial energy systems, considering the introduction of new technologies for example to integrate renewables or facilitate electrification. A sector-specific technology map to design a generic industrial symbiosis network, a comprehensive framework for synthetic industrial load-, generation-, and waste heat profile generation, as well as system modelling and optimization methods provide the methodological background of the work. Expected results include quantifiable reductions in CO2 emissions and exergy demand by industrial symbiosis.